Publications
» An aged immune system drives senescence and aging of solid organs. Yousefzadeh, M. J, Flores, R. R., Zhu, Y., Schmiechen, Z. C. , Brooks, R. W., Zhao, J., Sano, T., Angelini, L. A., Lee, K-A., Wade, E. A., Bukata, C., McGowan, S. J., Burrack, A. L., Harris, J. B., Ramgolam, I. E., Calubag, M. F., Bank, M. P., Trussoni, C. E., Kato, J. I., Melos, K., McGuckian, C. A., Wang, D., Dong, Q., Patil, P., Klug, J., Ladiges, W. L., Li, K., O'Kelly, R. D., Burd, C. E., LaRusso, N. F., Vo, N. V., Wang, Y., Kelley, E. E., Huard, J., Stomnes, I. M., Robbins, P. D.*, and Niedernhofer, L. J.* Nature, in press.
» Development of an IGF1R longevity variant mouse line. Dou, Y., Darvas, M., Sharma, K., Suh, Y., Mathieu, J., Morton, J., Tan, H., Niedernhofer, L. J., Robbins, P. D., Vijg, J., Barzilai, N., Ladiges, W. C. J. Trends. Biochem. Res., in press.
» Senolytics reduce coronavirus-related mortality in old mice. Camell, C. D., Yousefzadeh, M. J., Zhu, Y., Langhi Prata, L. G. P., Huggins, M. A., Pierson, M., Zhang, L., O'Kelly, R. D., Pirtskhalava, T., Xue, A., Tripathi, U., Espindola-Netto, J. M., Giorgadze, N., Atkinson, L. J., Inman, C. L., Johnson, K. O., Cholensky, Carlson, T. W., LeBrasseur, N. K., Khosla, S., O'Sullivan, M. G., Jameson, S. C., Prakash, Y. S., Chiarella, S. E., Hamilton, S. E.*, Tchkonia, T.*, Niedernhofer, L. J.*, Kirkland, J. L.* and Robbins, P. D.* Science, under revision.
» Genetic signature of human longevity in PKC and NF-kB signaling. Ryu, S., Han,J., Norden-Krichmar,T., Zhang, Q., Lee, S., Zhang, Z., Atzmon, G., Niedernhofer, L. J. Robbins, P. D., Barzilai, N., Schork, N. J. and Suh, Y. Aging Cell, in press.
» Novel small molecule inhibition of IKK/NF-kB activation reduces cellular senescence and improves healthspan in mouse models of accelerated and natural aging. Zhang, L., Zhao, J., Mu, X., McGowan, S. J., Angelini, L. A., O'Kelly, R. D., Yousefzadeh, M. J., Sakamoto, A., Aversa, Z., Lebrasseur, N. L., Suh, Y., Huard, J., Kamenecka, T. M., Niedernhofer, L. J. and Robbins, P. D. Aging Cell, under revision.
» Rare coding variants in conserved aging pathways contribute to human longevity and protection against AD and other age-related diseases. Lin, J. R., Sin-Chan, P., Mitra, J., Zhang, Q., Reza Jabalameli, M., Wang, Z., Nguyen, N., Gao, T., Holtzer, R., Ye, K., Shuldiner, A., Gorbunova, V., Ladiges, W. C., Niedernhofer, L. J., Robbins, P. D., Milman, S., Suh, Y., Vijg, J., Barzilai, N. and Z. D. Zhang. Nature Aging, under revision.
» A rare variant of SIRT6 identified in human centenarians improves genome maintenance and shows stronger interaction with Lamin A. Simon, M., Yang, J., Gigas, J., Schaff, T. M., Yu, S. L., Zhang, L., Zagorulya, M., Tombline, G., Gilbert, M., Pope, A., Van Meter, M., Emmrich, S., Han, J., Ryu, S, Tare, A., Zhu, Y., Hudgins, A., Atzmon, G., Barzilai, N., Wolfe, A., Moody, K., Garcia, B., Thomas, D. D., Robbins, P. D., Vijg, J., Seluanov, A., Suh, Y. and Gorbunova, V. Nature Cell Biology, submitted.
» Mesenchymal stem cell-derived extracellular vesicles reduce senescence and extend health span in mouse models of aging. Dorronsoro A, Santiago FE, Grassi D, Zhang T, Lai RC, McGowan SJ, Angelini L, Lavasani M, Corbo L, Lu A, Brooks RW, Garcia-Contreras M, Stolz DB, Amelio A, Boregowda SV, Fallahi M, Reich A, Ricordi C, Phinney DG, Huard J, Lim SK, Niedernhofer LJ, Robbins PD. Aging Cell. 2021 Mar 16:e13337. doi: 10.1111/acel.13337. Online ahead of print. pubmed
» Strategies to Prevent or Remediate Cancer and Treatment-Related Aging. Guida JL, Agurs-Collins T, Ahles TA, Campisi J, Dale W, Demark-Wahnefried W, Dietrich J, Fuldner R, Gallicchio L, Green PA, Hurria A, Janelsins MC, Jhappan C, Kirkland JL, Kohanski R, Longo V, Meydani S, Mohile S, Niedernhofer LJ, Nelson C, Perna F, Schadler K, Scott JM, Schrack JA, Tracy RP, van Deursen J, Ness KK. J Natl Cancer Inst. 2021 Feb 1;113(2):112-122. doi: 10.1093/jnci/djaa060. pubmed
» DNA damage-how and why we age?. Yousefzadeh M, Henpita C, Vyas R, Soto-Palma C, Robbins P, Niedernhofer L. Elife. 2021 Jan 29;10:e62852. doi: 10.7554/eLife.62852. pubmed
» Increased insulin sensitivity and diminished pancreatic beta-cell function in DNA repair deficient Ercc1(d/-) mice. Huerta Guevara AP, McGowan SJ, Kazantzis M, Stallons TR, Sano T, Mulder NL, Jurdzinski A, van Dijk TH, Eggen BJL, Jonker JW, Niedernhofer LJ, Kruit JK. Metabolism. 2021 Apr;117:154711. doi: 10.1016/j.metabol.2021.154711. Epub 2021 Jan 23. pubmed
» Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span. Robbins PD, Jurk D, Khosla S, Kirkland JL, LeBrasseur NK, Miller JD, Passos JF, Pignolo RJ, Tchkonia T, Niedernhofer LJ. Annu Rev Pharmacol Toxicol. 2021 Jan 6;61:779-803. doi: 10.1146/annurev-pharmtox-050120-105018. Epub 2020 Sep 30. pubmed
» ARDD 2020: from aging mechanisms to interventions. Mkrtchyan GV, Abdelmohsen K, Andreux P, Bagdonaite I, Barzilai N, Brunak S, Cabreiro F, de Cabo R, Campisi J, Cuervo AM, Demaria M, Ewald CY, Fang EF, Faragher R, Ferrucci L, Freund A, Silva-Garcia CG, Georgievskaya A, Gladyshev VN, Glass DJ, Gorbunova V, de Grey A, He WW, Hoeijmakers J, Hoffmann E, Horvath S, Houtkooper RH, Jensen MK, Jensen MB, Kane A, Kassem M, de Keizer P, Kennedy B, Karsenty G, Lamming DW, Lee KF, MacAulay N, Mamoshina P, Mellon J, Molenaars M, Moskalev A, Mund A, Niedernhofer L, Osborne B, Pak HH, Parkhitko A, Raimundo N, Rando TA, Rasmussen LJ, Reis C, Riedel CG, Franco-Romero A, Schumacher B, Sinclair DA, Suh Y, Taub PR, Toiber D, Treebak JT, Valenzano DR, Verdin E, Vijg J, Young S, Zhang L, Bakula D, Zhavoronkov A, Scheibye-Knudsen M. Aging (Albany NY). 2020 Dec 30;12(24):24484-24503. doi: 10.18632/aging.202454. Epub 2020 Dec 30. pubmed
» The Ercc1(-/delta) mouse model of accelerated senescence and aging for identification and testing of novel senotherapeutic interventions. Wong A, Kieu T, Robbins PD. Aging (Albany NY). 2020 Dec 22;12(24):24481-24483. doi: 10.18632/aging.202321. Epub 2020 Dec 22. pubmed
» Hitting the Bullseye: Are extracellular vesicles on target?. Noren Hooten N, Yanez-Mo M, DeRita R, Russell A, Quesenberry P, Ramratnam B, Robbins PD, Di Vizio D, Wen S, Witwer KW, Languino LR. J Extracell Vesicles. 2020 Nov;10(1):e12032. doi: 10.1002/jev2.12032. Epub 2020 Nov 29. pubmed
» Similar burden of pathogenic coding variants in exceptionally long-lived individuals and individuals without exceptional longevity. Gutman D, Lidzbarsky G, Milman S, Gao T, Sin-Chan P, Gonzaga-Jauregui C; Regeneron Genetics Center, Deelen J, Shuldiner AR, Barzilai N, Atzmon G. Aging Cell. 2020 Oct;19(10):e13216. doi: 10.1111/acel.13216. Epub 2020 Aug 29. pubmed
» Genetics of extreme human longevity to guide drug discovery for healthy ageing. Zhang ZD, Milman S, Lin JR, Wierbowski S, Yu H, Barzilai N, Gorbunova V, Ladiges WC, Niedernhofer LJ, Suh Y, Robbins PD, Vijg J. Nat Metab. 2020 Aug;2(8):663-672. doi: 10.1038/s42255-020-0247-0. Epub 2020 Jul 27. pubmed
» Cytoskeleton stiffness regulates cellular senescence and innate immune response in Hutchinson-Gilford Progeria Syndrome. Mu X, Tseng C, Hambright WS, Matre P, Lin CY, Chanda P, Chen W, Gu J, Ravuri S, Cui Y, Zhong L, Cooke JP, Niedernhofer LJ, Robbins PD, Huard J. Aging Cell. 2020 Aug;19(8):e13152. doi: 10.1111/acel.13152. Epub 2020 Jul 25. pubmed
» Pathogenic Mechanisms of Somatic Mutation and Genome Mosaicism in Aging. Vijg J, Dong X. Cell. 2020 Jul 9;182(1):12-23. doi: 10.1016/j.cell.2020.06.024. pubmed
» SIRT6 mono-ADP ribosylates KDM2A to locally increase H3K36me2 at DNA damage sites to inhibit transcription and promote repair. Rezazadeh S, Yang D, Biashad SA, Firsanov D, Takasugi M, Gilbert M, Tombline G, Bhanu NV, Garcia BA, Seluanov A, Gorbunova V. Aging (Albany NY). 2020 Jun 25;12(12):11165-11184. doi: 10.18632/aging.103567. Epub 2020 Jun 25. pubmed
» Attenuation of ataxia telangiectasia mutated signalling mitigates age-associated intervertebral disc degeneration. Han Y, Zhou CM, Shen H, Tan J, Dong Q, Zhang L, McGowan SJ, Zhao J, Sowa GA, Kang JD, Niedernhofer LJ, Robbins PD, Vo NN. Aging Cell. 2020 Jul;19(7):e13162. doi: 10.1111/acel.13162. Epub 2020 Jun 21. pubmed
» Field-deployable, rapid diagnostic testing of saliva samples for SARS-CoV-2. Wei S, Kohl E, Djandji A, Morgan S, Whittier S, Mansukhani M, Yeh R, Alejaldre JC, Fleck E, D'Alton M, Suh Y, Williams Z. medRxiv. 2020 Jun 16:2020.06.13.20129841. doi: 10.1101/2020.06.13.20129841. Preprint. pubmed
» Influences of circulatory factors on intervertebral disc aging phenotype. Lei C, Colangelo D, Patil P, Li V, Ngo K, Wang D, Dong Q, Yousefzadeh MJ, Lin H, Lee J, Kang J, Sowa G, Wyss-Coray T, Niedernhofer LJ, Robbins PD, Huffman DM, Vo N. Aging (Albany NY). 2020 Jun 11;12(12):12285-12304. doi: 10.18632/aging.103421. Epub 2020 Jun 11. pubmed
» A subset of microRNAs in the Dlk1-Dio3 cluster regulates age-associated muscle atrophy by targeting Atrogin-1. Shin YJ, Kwon ES, Lee SM, Kim SK, Min KW, Lim JY, Lee B, Kang JS, Kwak JY, Son YH, Choi JY, Yang YR, Kim S, Kim YS, Jang HC, Suh Y, Yoon JH, Lee KP, Kwon KS. J Cachexia Sarcopenia Muscle. 2020 Oct;11(5):1336-1350. doi: 10.1002/jcsm.12578. Epub 2020 Jun 3. pubmed
» Direct diagnostic testing of SARS-CoV-2 without the need for prior RNA extraction. Wei S, Kohl E, Djandji A, Morgan S, Whittier S, Mansukhani M, Hod E, D'Alton M, Suh Y, Williams Z. medRxiv. 2020 Jun 2:2020.05.28.20115220. doi: 10.1101/2020.05.28.20115220. Preprint. pubmed
» Heterochronic parabiosis regulates the extent of cellular senescence in multiple tissues. Yousefzadeh MJ, Wilkinson JE, Hughes B, Gadela N, Ladiges WC, Vo N, Niedernhofer LJ, Huffman DM, Robbins PD. Geroscience. 2020 Jun;42(3):951-961. doi: 10.1007/s11357-020-00185-1. Epub 2020 Apr 13. pubmed
» ATM is a key driver of NF-_B-dependent DNA-damage-induced senescence, stem cell dysfunction and aging. Zhao J, Zhang L, Lu A, Han Y, Colangelo D, Bukata C, Scibetta A, Yousefzadeh MJ, Li X, Gurkar AU, McGowan SJ, Angelini L, O'Kelly R, Li H, Corbo L, Sano T, Nick H, Pola E, Pilla SPS, Ladiges WC, Vo N, Huard J, Niedernhofer LJ, Robbins PD. Aging (Albany NY). 2020 Mar 22;12(6):4688-4710. doi: 10.18632/aging.102863. Epub 2020 Mar 22. pubmed
» Transcriptome analysis reveals the difference between healthy and common aging and their connection with age-related diseases. Zeng L, Yang J, Peng S, Zhu J, Zhang B, Suh Y, Tu Z. Aging Cell. 2020 Mar;19(3):e13121. doi: 10.1111/acel.13121. Epub 2020 Feb 19. pubmed
» Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice. Yousefzadeh MJ, Zhao J, Bukata C, Wade EA, McGowan SJ, Angelini LA, Bank MP, Gurkar AU, McGuckian CA, Calubag MF, Kato JI, Burd CE, Robbins PD, Niedernhofer LJ. Aging Cell. 2020 Mar;19(3):e13094. doi: 10.1111/acel.13094. Epub 2020 Jan 25. pubmed
» Human geroprotector discovery by targeting the converging subnetworks of aging and age-related diseases. Yang J, Peng S, Zhang B, Houten S, Schadt E, Zhu J, Suh Y, Tu Z. Geroscience. 2020 Feb;42(1):353-372. doi: 10.1007/s11357-019-00106-x. Epub 2019 Oct 21. pubmed
» Association of Lipidomic Profiles With Progression of Carotid Artery Atherosclerosis in HIV Infection. Chai JC, Deik AA, Hua S, Wang T, Hanna DB, Xue X, Haberlen SA, Shah SJ, Suh Y, Lazar JM, Gustafson D, Hodis HN, Landay AL, Anastos K, Post WS, Kaplan RC, Clish CB, Qi Q. JAMA Cardiol. 2019 Dec 1;4(12):1239-1249. doi: 10.1001/jamacardio.2019.4025. pubmed
» Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy. Nogueira-Recalde U, Lorenzo-Gomez I, Blanco FJ, Loza MI, Grassi D, Shirinsky V, Shirinsky I, Lotz M, Robbins PD, Dominguez E, Carames B. EBioMedicine. 2019 Jul;45:588-605. doi: 10.1016/j.ebiom.2019.06.049. Epub 2019 Jul 5. pubmed
» Systemic clearance of p16(INK4a) -positive senescent cells mitigates age-associated intervertebral disc degeneration. Patil P, Dong Q, Wang D, Chang J, Wiley C, Demaria M, Lee J, Kang J, Niedernhofer LJ, Robbins PD, Sowa G, Campisi J, Zhou D, Vo N. Aging Cell. 2019 Jun;18(3):e12927. doi: 10.1111/acel.12927. Epub 2019 Mar 21. pubmed
» Murine models of accelerated aging and musculoskeletal disease. Hambright WS, Niedernhofer LJ, Huard J, Robbins PD. Bone. 2019 Aug;125:122-127. doi: 10.1016/j.bone.2019.03.002. Epub 2019 Mar 4. pubmed
» Mouse Models of Accelerated Cellular Senescence. Yousefzadeh MJ, Melos KI, Angelini L, Burd CE, Robbins PD, Niedernhofer LJ. Methods Mol Biol. 2019;1896:203-230. doi: 10.1007/978-1-4939-8931-7_17. pubmed
» mTOR inhibitors may benefit kidney transplant recipients with mitochondrial diseases. Johnson SC, Martinez F, Bitto A, Gonzalez B, Tazaerslan C, Cohen C, Delaval L, Timsit J, Knebelmann B, Terzi F, Mahal T, Zhu Y, Morgan PG, Sedensky MM, Kaeberlein M, Legendre C, Suh Y, Canaud G. Kidney Int. 2019 Feb;95(2):455-466. doi: 10.1016/j.kint.2018.08.038. Epub 2018 Nov 22. pubmed
» Development of Clinical Trials to Extend Healthy Lifespan. Justice JN, Niedernhofer L, Robbins PD, Aroda VR, Espeland MA, Kritchevsky SB, Kuchel GA, Barzilai N. Cardiovasc Endocrinol Metab. 2018 Dec;7(4):80-83. doi: 10.1097/XCE.0000000000000159. pubmed
» Cellular senescence in intervertebral disc aging and degeneration. Patil P, Niedernhofer LJ, Robbins PD, Lee J, Sowa G, Vo N. Curr Mol Biol Rep. 2018 Dec;4(4):180-190. doi: 10.1007/s40610-018-0108-8. Epub 2018 Oct 25. pubmed
» In vivo epigenome editing and transcriptional modulation using CRISPR technology. Lau CH, Suh Y. Transgenic Res. 2018 Dec;27(6):489-509. doi: 10.1007/s11248-018-0096-8. Epub 2018 Oct 4. pubmed
» Fisetin is a senotherapeutic that extends health and lifespan. Yousefzadeh MJ, Zhu Y, McGowan SJ, Angelini L, Fuhrmann-Stroissnigg H, Xu M, Ling YY, Melos KI, Pirtskhalava T, Inman CL, McGuckian C, Wade EA, Kato JI, Grassi D, Wentworth M, Burd CE, Arriaga EA, Ladiges WL, Tchkonia T, Kirkland JL, Robbins PD, Niedernhofer LJ. EBioMedicine. 2018 Oct;36:18-28. doi: 10.1016/j.ebiom.2018.09.015. Epub 2018 Sep 29. pubmed
» Senolytics improve physical function and increase lifespan in old age. Xu M, Pirtskhalava T, Farr JN, Weigand BM, Palmer AK, Weivoda MM, Inman CL, Ogrodnik MB, Hachfeld CM, Fraser DG, Onken JL, Johnson KO, Verzosa GC, Langhi LGP, Weigl M, Giorgadze N, LeBrasseur NK, Miller JD, Jurk D, Singh RJ, Allison DB, Ejima K, Hubbard GB, Ikeno Y, Cubro H, Garovic VD, Hou X, Weroha SJ, Robbins PD, Niedernhofer LJ, Khosla S, Tchkonia T, Kirkland JL. Nat Med. 2018 Aug;24(8):1246-1256. doi: 10.1038/s41591-018-0092-9. Epub 2018 Jul 9. pubmed
» Dysregulation of DAF-16/FOXO3A-mediated stress responses accelerates oxidative DNA damage induced aging. Gurkar AU, Robinson AR, Cui Y, Li X, Allani SK, Webster A, Muravia M, Fallahi M, Weissbach H, Robbins PD, Wang Y, Kelley EE, Croix CMS, Niedernhofer LJ, Gill MS. Redox Biol. 2018 Sep;18:191-199. doi: 10.1016/j.redox.2018.06.005. Epub 2018 Jun 19. pubmed
» Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-_B activation. Zhao J, Zhang L, Mu X, Doebelin C, Nguyen W, Wallace C, Reay DP, McGowan SJ, Corbo L, Clemens PR, Wilson GM, Watkins SC, Solt LA, Cameron MD, Huard J, Niedernhofer LJ, Kamenecka TM, Robbins PD. PLoS Biol. 2018 Jun 11;16(6):e2004663. doi: 10.1371/journal.pbio.2004663. eCollection 2018 Jun. pubmed
» Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging. Robinson AR, Yousefzadeh MJ, Rozgaja TA, Wang J, Li X, Tilstra JS, Feldman CH, Gregg SQ, Johnson CH, Skoda EM, Frantz MC, Bell-Temin H, Pope-Varsalona H, Gurkar AU, Nasto LA, Robinson RAS, Fuhrmann-Stroissnigg H, Czerwinska J, McGowan SJ, Cantu-Medellin N, Harris JB, Maniar S, Ross MA, Trussoni CE, LaRusso NF, Cifuentes-Pagano E, Pagano PJ, Tudek B, Vo NV, Rigatti LH, Opresko PL, Stolz DB, Watkins SC, Burd CE, Croix CMS, Siuzdak G, Yates NA, Robbins PD, Wang Y, Wipf P, Kelley EE, Niedernhofer LJ. Redox Biol. 2018 Jul;17:259-273. doi: 10.1016/j.redox.2018.04.007. Epub 2018 Apr 13. pubmed
» Effective discovery of rare variants by pooled target capture sequencing: A comparative analysis with individually indexed target capture sequencing. Ryu S, Han J, Norden-Krichmar TM, Schork NJ, Suh Y. Mutat Res. 2018 May;809:24-31. doi: 10.1016/j.mrfmmm.2018.03.007. Epub 2018 Mar 30. pubmed
» Cell Replacement to Reverse Brain Aging: Challenges, Pitfalls, and Opportunities. Hebert JM, Vijg J. Trends Neurosci. 2018 May;41(5):267-279. doi: 10.1016/j.tins.2018.02.008. Epub 2018 Mar 13. pubmed
» Age- and Tissue-Specific Expression of Senescence Biomarkers in Mice. Hudgins AD, Tazearslan C, Tare A, Zhu Y, Huffman D, Suh Y. Front Genet. 2018 Feb 23;9:59. doi: 10.3389/fgene.2018.00059. eCollection 2018. pubmed
» Global, integrated analysis of methylomes and transcriptomes from laser capture microdissected bronchial and alveolar cells in human lung. Dong X, Shi M, Lee M, Toro R, Gravina S, Han W, Yasuda S, Wang T, Zhang Z, Vijg J, Suh Y, Spivack SD. Epigenetics. 2018;13(3):264-274. doi: 10.1080/15592294.2018.1441650. Epub 2018 May 10. pubmed
» Integrated rare variant-based risk gene prioritization in disease case-control sequencing studies. Lin JR, Zhang Q, Cai Y, Morrow BE, Zhang ZD. PLoS Genet. 2017 Dec 27;13(12):e1007142. doi: 10.1371/journal.pgen.1007142. eCollection 2017 Dec. pubmed
» In vivo genome editing in animals using AAV-CRISPR system: applications to translational research of human disease. Lau CH, Suh Y. F1000Res. 2017 Dec 20;6:2153. doi: 10.12688/f1000research.11243.1. eCollection 2017. pubmed
» Senescent intervertebral disc cells exhibit perturbed matrix homeostasis phenotype. Ngo K, Patil P, McGowan SJ, Niedernhofer LJ, Robbins PD, Kang J, Sowa G, Vo N. Mech Ageing Dev. 2017 Sep;166:16-23. doi: 10.1016/j.mad.2017.08.007. Epub 2017 Aug 19. pubmed